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Waseda's Regimen
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Re: Waseda: 

From: waseda
Date: 30 Mar 2001
Time: 10:43:30
Remote Name: 211.120.78.169

Comments

First, big news. I received e-mail from the original researcher of bayberry, Dr. Matsuda.

"Extracting 1g bayberry bark root with 5ml 50% ethanol solution, and putting 1/10 of the solution on the target. The INHIBITING RATE OF DHT was 80.7%."

Hey, you out there all know the inhibiting rate of DHT by Finasteride, of course. Bayberry root is without doubt safe, because it has been used for health for hundreds of years both in Europe and Asia. That safe, cheap root has found to inhibit the DHT by 80.7%!!! Do you smile? I feel happy.

We were discouraged recently because we found not to be able to get Dutasteride, RU58841 soon. But, suddenly two safe alternatives, S-maltoside and bayberry ---I mean, these are really gettable----appear in front of us.

He was kindly enough to send paper to me and I am sure to report the exact content in this forum in a couple of days.

************

Small corrections:

Step 1: The resultant solution will be very condensed, ie. 50ml-70ml. You need not the ground in Step 1.

Step 2: You must leave the ground in Step 2.

The final solution contains muddy stuff, but never mind it. You apply the top layer. The sandy ground is only rosehip or so, but don't throw away it. Stir the solution at the time of applying

To Waseda: S-maltoside and Bayberry

From: Z
Date: 30 Mar 2001
Time: 11:45:05
Remote Name: 148.126.100.80

Comments

Waseda

You are simply amazing. :-) Thanks for the info on these two herbs.

So do we add these two herbs to Morehairin? If so, would you be kind enough to post the exact amount? Furthermore, would this change the amount of the vehicle (alcohol or Dermovan)?

It will be interesting to know whether these two herbs reduce DHT only or they downregulate the scalp androgen receptors. If it is the latter, then these ingredients are truly incredible and as you stated previously, this puts them in the same class as RU-58841.

Bayberry is available on the 'net, however the search for S-maltoside yielded absolutely nothing.

Thanks again. Z

Re: To Waseda: S-maltoside and Bayberry

From: waseda
Date: 30 Mar 2001
Time: 12:05:42
Remote Name: 211.120.78.169

Comments

After scrutinizing the paper, I will post the exact how to make of or how to add to of bayberry.

S-maltoside is the main ingredient of Pola's Growing Shot S to come on 4/25. It is really topical, local. I am now persuading the staff of Pola to serve internationl order homepage in English. They don't understand the importance of their product for worldwide hair-loss men. They worry about the relationship with their business partner (a big pharmaceutical company which sell minox in Japan). Pola's concern is S-maltoside is superior to minox

S-maltoside and Bayberry

From: BaldyBill
Date: 30 Mar 2001
Time: 12:20:38
Remote Name: 168.39.181.197

Comments

Incredible and wonderful news! I can buy bayberry easily at a nearby healthfood store. Actually took bayberry internally in the past so I'm familiar with it.

I especially like what you said about the effectiveness as compared with Minoxidil, as I have been using Minox for 7 years now and am looking for a way to get off of it without losing too much hair. I very much prefer the natural approach to hair regrowth

Waseda : bayberry tincture source

From: iap
Date: 30 Mar 2001
Time: 17:42:50
Remote Name: 205.167.155.9

Comments

http://www.healthherbs.com/products/SINGLEHERBTINCTURES/
bayberry-3090.htm

waseda: think this might work

Re: Waseda : bayberry tincture source

From: waseda
Date: 31 Mar 2001
Time: 07:40:36
Remote Name: 211.132.33.230

Comments

GSE of Country Life you recommened arrived today. It seems to be of high quality. I 'll try to make Morehairin using this. Thank you.

Bayberry Study by Dr. Matsuda et al.

From: waseda
Date: 02 Apr 2001
Time: 05:31:31
Remote Name: 211.132.39.221

Comments

Anti-androgenic Activity of Miricae Cortex---Isolation of Active Constituents from Bark of Myrica rubra (Biol. Pham. Bull. 24(3), March 2001) by Hideaki Matsuda et. al. consists of roghly three parts.

First, they carries out screening of 20 herbs on inhibition rate of testosterone 5 alpha reductase activity, though they don't seperate type one and type two. Top five of inhibition rate of activity in vitro by 50% ethanol extracts are

Myrica rubra Sieb. et Zucc (so called bayberry ) : 80.7%

Rosa rugosa Thunb. var. plena Regel (so called Ramanas rose, naturalized in several places in Britain) : 79.0%

Mucuna birdwoodiana Tutcher : 58.4% Polygonum bistorta L. (so called BISTORT, SNAKEWEED, EASTER LEDGES) : 58.2%

Polygonum multiforum Thunb. (so called He Shou Wu, Fo-Ti) : 57.4%

Next, they pay attention to the top two plants and study the tesosterone-stimulated growth suppression of Hamster Flank Organs in terms of pigment macule areas(mm2). Their comparison standard is oxendolone.

Testosterone + 50% ethanol (control) left(untreatd) 7.2 right(treated) 19.4 inhibition rate 0%

Testosterone + bayberry extract 0.5mg 7.1 11.8 39%

Testosterone + Rosa rugosa 0.5mg 6.1 10.1 48%

Testosterone + oxendolone 0.33micor mol 4.8 12.8 34%

In short, bayberry extract inhibits the growth of right flank organ stimulated by testosterone by 39% locally, while oxendolone inhibits it by 34% and partially syemicaly(left organ is also suppressed).

Though Rosa rugosa inhibits the growth by as large as 48%, it works a bit systemically( see the figure 6.1 < 7.2).

Third, they study the recovery scores of topical applications of stuffs from testosterone deppressed hair of mouse in shaved area. Score 1: less than 20% growth of hair, 20%<=score 2<40%, 40%<=score 3<60%, 60%<score 4<80%, 80%<= score 5<100%. After 25 days of applications,

control : 3.5

2% oxendolone : 3.0

bayberry extract : 2.5

rosa rugosa : 2.0

testosterone treated : 1.2

graphically read. This means mouse's hairs applied with bayberry extract will regrow 2.5/3.5=71% in score compared to no androgenic hairs and grow about twice(2.5/1.2) in score of testosterone treated hairs.

************

We can conclude that bayberry extract will be a potent topical (local) 5 alpha reductase inhibitor.

According to Dr. Matsuda, this study was done under the cooperation with a pharmaceutical company, but this stuff has color and spots cloths, and they have not manufactured it product. "Please apply it freely among hair loss people all over the world." This is his message.

-- waseda

Re: Bayberry Study by Dr. Matsuda et al.

From: shasmi
Date: 02 Apr 2001
Time: 06:33:25
Remote Name: 195.92.194.19

Comments

waseda, dose this mean it will have the same effect on humans as it dose on hamster flanks? could it turn out that it dosen`t have quite the same effect on the human scalp in any way. are these test a good indication model for humans

Re: Bayberry Study by Dr. Matsuda et al.

From: waseda
Date: 02 Apr 2001
Time: 17:52:51
Remote Name: 211.13.140.105

Comments

This is an answer I posted on alt.baldspot in response to Bryan.

Bryan wrote: >Were these castrated or non-castrated animals? >The 7.2 mm^2 figure would appear to be too HIGH for castrated >hamsters, but too LOW for non-castrated ones. I'm puzzled...

"Pre-pubertal male Syrian golden hamsters were castrated at 3 weeks of age by excision of the testicles. Intact hamsters were not castrated. (snip) Growth of both flank organs, treated(right side) and vehicle(left side) was determined by measurinf the length of the long axis and the short axis of the pigmented spot (pigmented macule) with calipers. The surface area (mm2) of the spot was calculated by multiplication of length of the two axis."

And only testosterone applied data are (mm2)(Table 3):

Intact left(vehicle) 32.7 right(vehicle) 30.6

castrated left(vehicle)9.8 right(vehicle)9.1

castrated + testosterone left(vehicle)9.5 right(testrosterone)22.1

vehicle: 5microlittre ethanol

testosterone 0.5micrograms per 5microlittre

ethanol(0.01%)

days: 21 days

And as you say these are the figures of *increase* in area of pigmented macule. Sorry, I would have referred to.

>right(treated) 19.4 inhibition rate 0%

>Also, what was the dose of testosterone that they used, >and how long was the treatment period?

days: 21 days

testosterone dose: above

>Testosterone + bayberry extract 0.5mg 7.1 11.8 39%

>Testosterone + Rosa rugosa 0.5mg 6.1 10.1 48%

>Testosterone + oxendolone 0.33micor mol 4.8 12.8 34%

> >In short, bayberry extract inhibits the growth of right flank organ >stimulated by testosterone by 39% locally

>I wouldn't phrase it that way. To my way of thinking, if testosterone >normally increases the size from 7.2 to 19.4, and you do something >that reduces the increase from 7.2 to only 11.8, that's an inhibition >of (12.2 - 4.6) / 12.2 = about 62%, not 39%, of the testosterone itself.

No. To my understanding of authors' intention, the possible growth if testosterone would be applied was 19.4, and it is reduced to 11.8, then inhibition rate of flank organ by bayberry extract is (19.4-11.8)/19.4=39%. Similarly, for rose rugosa, (19.4-10.1)/19.4=48%. The above figures are same as the table 4 of original paper and the inhibition rates are only citation but not my calculation.

>Third, they study the recovery scores of topical applications of stuffs >from testosterone deppressed hair of mouse in shaved area. Score 1: >less than 20% growth of hair, 20%<=score 2<40%, 40%<=score 3<60%, >60%<score 4<80%, 80%<= score 5<100%. After 25 days of applications,

>The testosterone was *suppressing* growth of hair in mice?

Yes, the data shows it. These are C57Black/6CrSlc mice. They are testosterone sensitive male strain mice. They can be thought of good models of MPB humans, though we can't say one to one corrspondense.

>Was this transplanted human scalp hair?

I don't know. According to the author, because the stuff stained, they stopped the development.

**********

They made bayberry extract as follows:

Crush to powder 100g of bayberry extract with 50% ethanol 500ml for 24 hours at room temperature. They used Japanese bayberry (Yamamomo), Myrica rubra, but the author told me Chinese bayberry has the same effeciency. So, if you try it, you had better get bayberry bark root from Chinese herbal shops or web-net shops.

Chinese name is 'Yang Mei'

Re: Bayberry Study by Dr. Matsuda et al.

From: waseda
Date: 02 Apr 2001
Time: 17:56:20
Remote Name: 211.132.34.228

Comments

If you make it, don't forget to extract bayberry bark root with 50% ethanol.

Ration: 100g : 500ml (50% ethanol water solution

to waseda

From: Follicularly Impaired
Date: 03 Apr 2001
Time: 13:16:23
Remote Name: 206.133.127.78

Comments

Ahh the process of modern day Alchemisim continues, Merlin would indeed be proud! Quick question, do you think it's possible to mix the entire morehairin soultion in with the Bayberry. Both sauces contain ethanol ( at least if you can get it). That way we wouldn't have to be putting 4 seperate concoctions on our heads daily. Thanks in advance...FI

Re: to waseda

From: waseda
Date: 04 Apr 2001
Time: 08:14:22
Remote Name: 211.132.37.54

Comments

We can mix them all. But one caution:

Bayberry bark root must be crushed (to powder) before extracting(with 50% ethanol). After 24 to 48 hours extraction, filter through thin cloth

Waseda: bayberry

From: iap
Date: 03 Apr 2001
Time: 18:38:26
Remote Name: 205.167.155.9

Comments

thanks for the feed back on the various genuses of bayberry - i have it on moderately good authority (not definitive) that the bayberry family is essentially all 'equal' - that the indigenous american bayberry is equivilant to asian bayberry....

Re: Waseda: bayberry

From: waseda
Date: 04 Apr 2001
Time: 09:15:53
Remote Name: 211.132.38.218

Comments

It's a good news!

BTW: how to make bayberry extract:

Crush 100g bayberry bark root to powder and steep it in 500ml 50% ethanol water solution for 24 hours to 48 hours and filter the solution. This is the way the paper stated

Re: waseda: is there some way you can show me the kanji character...

From: wased
Date: 05 Apr 2001
Time: 17:57:48
Remote Name: 211.132.38.131

Comments

You can find 'Search' in

http://zhongwen.com/m/search.htm

and put Yang into 'Pronunciation' and Go.

You can find 'yang' at the third character in the second line.

Similarily, put 'mei' into 'Pronunciation' and Go. The fifth character in the first line is the correspondent character. Put 'pi', and the third character in the second line is 'pi' meaning bark of tree.

Thus you found the 'bayberry bark' as 'yang' 'mei' 'pi', Yangmeipi

BAYBERRY ? Chinese herbal store

From: Blue
Date: 06 Apr 2001
Time: 09:24:52
Remote Name: 202.134.1.132

Comments

regarding the use of bayberry. i was trying to find it at my local chinese herbal shop. they said there are nothing by the name "yang mei" or "yang mei pi" the only similar name is "wu mei" which is sort of like dried prune from it's looks. can u tell me where can i find this. or even help me to find the chinese character or kanji so it will be easier to look in chinese herbal shops. thank u

BAYBERRY (Myrica rubra - "Yang Mei Pi" in Chinese pinyin) is NOT a Chinese herbal medicine; you will not find it in any Chinese herbal store. WASEDA, please post if you know where to get it. Thanks!

From:
Date: 07 Apr 2001
Time: 13:00:19
Remote Name: 139.175.57.120

Comments

Contact with this site: http://www2.odn.ne.jp/~shanghai/order1.html

From: waseda
Date: 07 Apr 2001
Time: 22:30:54
Remote Name: 211.132.38.252

Comments

bayberry

From: iap
Date: 06 Apr 2001
Time: 10:58:19
Remote Name: 128.193.168.173

Comments

Bayberry; you can buy it here

From: Andy-s@mail.com
Date: 08 Apr 2001
Time: 06:54:31
Remote Name: 213.142.69.142

Comments

You can buy Bayberry (Myrica rubra db)dried berries from China at this site

http://www.sheffields.com/sheffields/catalog/

Choose Botanical, the letter M, push "Find", scroll all the way down to "MYRICA rubra db" and hit "Display Details...."

BUT, I can not remember whether or not Waseda recommend the dried berry, the plantroot, the bark, the leaf.

Can anyone answer my question?

Re: Bayberry; you can buy it here

From: tintinet
Date: 08 Apr 2001
Time: 07:31:04
Remote Name: 129.37.94.130

Comments

I believe it's bayberry root bark, which one can also find here:

http://shop.store.yahoo.com/alteredstatesherbs/bayrootbarpo.html

Shanghai Sahanji will distribute Chinese bayberry (Myrica rubra)

From: waseda
Date: 08 Apr 2001
Time: 18:52:52
Remote Name: 211.132.34.179

Comments

I phoned to Shanghai Sahanji site and they said they would distribute Cninese bayberry (Myrica rubra) in powdered form in plastic bag.

Please contact with

sy-mie-b@par.odn.ne.jp

Bayberry question driving me nuts !

From: BaldyBill
Date: 09 Apr 2001
Time: 09:57:41
Remote Name: 168.39.181.202

Comments

What is the difference between Myrica Rubra and Myrica Cerifera? They are both listed as Bayberry. So far no luck with internet searches and it's kind of frustrating. Called local herb shop and even they don't know. MY GUESS- the Cerifera is the bark, and the Rubra is the fruit, but it comes from the same plant.

Anybody out there know for sure?? Also, if I'm right, then do we use the fruit or the bark

Re: Bayberry question driving me nuts !

From: shasmi
Date: 09 Apr 2001
Time: 10:43:15
Remote Name: 195.92.194.20

Comments

one`s native to america and the other, china