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Waseda,
why so excited about topical fin?
From:
MS
Date: 10/1/2001
Time: 4:41:53 PM
Remote Name: 152.163.194.184
Comments
Waseda, although I
am aware that at some point Merck tested Fin topically (concluded
compliance not good vs. oral), Fin has never
been acknowledged to be as good an "anti-androgen" (or 5ar
inhibitor) as other agents including Spiro and as far as I can
tell EGCG or
"newer" agents such as freeform fatty-acids and GSE.
What about it make you
feel it is the "ideal" topcial?
Wouldn't
you think a regimen that includes Spiro, Bayberry, EGCG, GSE would
attack androgens and dht-conversion topically as
well as anything?
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Re:
Waseda, why so excited about topical fin?
From: waseda
Date: 10/2/2001
Time: 1:51:40 PM
Remote Name: 211.120.76.17
Comments
Recent
studies have gradually revealed some pathways where DHT causes hair
loss. A main root is that DHT promotes caspase
3, 9, etc. Caspases
are cysteine proteases which cause cell apoptosis when activated.
For example, it is found that DHT promotes TGF-beta2
which activates caspase 9 and the activated caspase 9 propagates the
activity toward the downstrem caspase 3. This
progresses the keratinocytes' apoptosis. Keratinocytes' apoptosis
means just the start of catagen phase.
Thus
our strategy for preventing AGA contains 1) blocking DHT or blocking
5AR which converts testostelone to DHT, 2) inhibiting
TGF-beta family ( I will show soon how to do for that purpose), 3)
blocking the caspase activity cascade.
I directed my
attention to Dr. Sawaya's new study in Tokyo conference this year
that Finasteride may effect directly on caspase regulation.
"(snip)AGA affected
tissues showed an increase in caspase (-1, -3, -6, -9)
immunoreactivity with a concomitant decrease in XIAP
staining. After 6 months of finasteride treatment both caspases and
XIAP were similar to levels exhibited by normal subjects.
Immunoblot analysis was performed to determine antibody specificity
and cellular expression of caspases. (snip) finasteride
appears to influence caspase and XIAP expression in hair follicle
cells thus signaling anagen, active growth in the hair cycle".
(Effects of Finasteride on Apoptosis and Regulation of the Human
Hair Cycle. Marty E. Sawaya et.al)
To
tell the truth, I am already satisfied with spiro+bayberry for
preventing androgens. But, I have been thinking about many posts
here claiming 'Topical Fin with greasy base really works far better
than oral Fin'. My
intuition is that perhaps topical creamy finasteride application
might work more directly on the inhibition of caspase activity
cascade |
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