ANALYSIS ON HAIR LOSS
The start of catagen
phase of hair is now thought of being equal to the initiation of hair
cells apoptosis. Thus caspase 9 and/or caspase
3 are detected around catagen hair cells in many studies.
Then what induces
caspase activation cascade and what blocks or stops the cascade stream in
the context of hair loss?
Protein Kinase C family as an executor of apoptosis:
Safe and quick acting inhibitor of PKC as well as TNF-alpha inhibitor is perilla leaf extract (4) and Amashiso spray for preventing hair fall out uses it as one ingredient.
TNF-alpha as a promotor of PKC and hair cell apoptosis
TNF-alpha induces PKC
family and causes cell death through its induction (5).
This pathway is known to be one major cause of
hair loss (6). Notice that "
their (=TNF-alpha + IL-1) injection significantly upregulated apoptosis
after 6 h, which was further
increased after 24 h". We may interpret TNF-alpha as a quick
effecting proinflammatory cytokine. We may guess TNF-alpha
is over-secreted if we see rapid hair loss.
Then what inhibits the dangerous TNF-alpha safely?
It's just perilla leaf extract and it also inhibits PKC which interacts with TNF-alpha (7),(8).
TGF-beta family as the bridge between DHT and caspases activation cascade
The big progress in
hair loss study is researchers have found DHT promotes TGF-beta family and
TGF-beta family cause caspases
activation cascade and thus hair cell death, which means premature catagen
outbreak, meaning AGA. For example, see
(9), (10). Thus
it is possible that premature catgen will be prevented by TGF-beta
suppression. But, what inhibits the TGF-beta safely instead
of e.g. dangerous anti-cancer stuff? Shiseido's study found it is near us.
It is Amacha (Hydrangea macrophylla).
Therefore, we have
three powerful causes of hair loss besides DHT, that is PKC,
TNF-alpha, TGF-beta and we already know we
have only to inhibits them in order to prevent premature catagen outbreak
or unexpected hair fall outs.
spray contains 1) Shiso (=perilla leaf extract) for inhibiting PKC and TNF-alpha
2) Amacha (=Hydrangea macrophylla)
for ihnibiting TGF-beta and 3) Senburi extract as base liquid.
Ama means sweet and cha
means tea. Amacha(Hydrangea macrophylla Seringe var. thunbergii Makino)
has been long used in far east area
for sugar alternative among diabetes patients. It's empirically safe.
One answer is this.
"These results not
only support the concept that one of the major functions of TGF-beta1 is
the regulation through apoptosis of the
anagen-catagen transition during the hair cycle (13),
but also suggest that dysregulation of this process can lead to a hyperproliferative
phenotype. The reversibility of hair loss in this model suggests that
essential cellular components for hair follicle
formation such as the stem cells are resistant to the apoptotic effects of
TGF-beta1 and can regenerate afunctional hair follicle
once TGF-beta1 expression is suppressed. Given the strong growth
inhibitory effects of TGF-beta1 on keratinocytes, it seems
unlikely thatTGF-beta1 becomes a direct mitogen in this setting, but
rather that growth inhibition by TGF-beta1 is blocked.
If so, do we think much of TGF-beta suppressor such as Amacha extract next to DHT suppressor such as spiro, finasteride, bayberry. etc, for our 'reversibility of hair loss'?
Adding Amacha to Souhakuhi
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