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WASEDA'S REGIMEN |
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WASEDA'S COMPREHENSIVE
ANALYSIS ON HAIR LOSS
(9) Androgen-inducible TGF-beta1 Derived from Dermal Papilla Cells Mediates Hair Growth Suppression in Androgenetic Alopecia. Shigeki Inui, Yoko Fukuzato, Takeshi Nakajima, Kunihiko Yoshikawa, Satoshi Itami Department of Dermatology, Osaka University
Medical School(http://www.ehrs.org/conferenceabstracts/2001tokyo We further examined the change of expression level of mRNA of various factors in bald DPCs cocultured with keratinocytes after androgen treatment by semiquantitative RT-PCR and found that TGF-beta1 was increased by androgen in bald DPCs. Moreover, the neutralizing anti-TGF-beta1 antibody antagonized the inhibition of keratinocyte proliferation in this co-culture system in a dose dependent manner. From these data obtained using our novel powerful coculture model for AGA, we suggest that androgen-inducible TGF-beta1 derived from DPCs mediates hair growth suppression in AGA.
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