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 WSMR'S FLEXIBLE PEPTIDE S 
FAQ & SAFETY PROFILE

What is FLEX S1, 2?
Flexible Peptide S or FLEX S1, 2 are two versions of synthetic polypeptides (chains of amino acids in a specific sequence) that are applied to the scalp to stimulate hair growth over the entire scalp, not just the crown.  They are named for their flexible characteristics when binding to the hair follicle cells.

How does FLEX S1, 2 work?
Our researchers have found that DHT (dihydrotestosterone) hormone levels play a key role in the slow development of male pattern baldness, but there are other negative factors that "shut down" the hair follicle much faster by binding to a specific cellular receptor site on the surface of the hair follicle cells.

Once these negative factors bind to the specific receptor site and "switch off" the follicle, hair loss and thinning of the hair diameter can occur at a frightening rate. 

FLEX S1, 2 work directly on these hair follicle scalp receptors and "switch on" the hair follicle.  This not only places the follicles back into growth phase but stimulates the follicle to increase back to a normal diameter and colour.

What about the slick bald areas or temples, does FLEX S1, 2 work there?
We have found FLEX S1, 2 to initiate hair growth in all areas of the human scalp with equal potency.  Furthermore, our researchers have found that even in slick bald areas of the scalp, all of the hair follicles remain, though in a miniaturized state.  It now appears that all of the hair may be restored with continued application.

How well does FLEX S1, 2 work?
Growth in all subjects occurred within 40 days over the entire scalp.  Tiny vellus hairs began to become darkly coloured and large (terminal) at approximately 90 days of application,  please see the Photo section.

  How long will it take to restore full density of hair? 
That would depend on several factors, though our current theory estimates it to take between one third (1/3) and one half (1/2) of the time that a patient was losing their hair to replenish the scalp to full density.  This may change as research proceeds.

  Once available, will I have to use the treatment forever? 
Once hair is restored to a cosmetically acceptable result, it is anticipated that the patient would have to continue application to ensure continued hair growth.

These are the questions that we are working hard at in a research setting now.

How often was FLEX S1, 2 applied?
In the initial study, the FLEX S synthetic peptides were applied in our SeaGulls delivery vehicle nightly. 

Were there any negative side effects noted?
The only negative side effect noted was a contact rash in 5% of the subjects. 

Is FLEX S1, 2 effective in other forms of hair loss?
We are currently testing other Flexible and Folding peptides in other forms of alopecia, but it is too early to determine effectiveness at this stage

FLEX S1, 2 - SAFETY PROFILE
The initial safety profile of Flex S1,2 has been established.  The synthetic peptide does not inhibit wound healing and is not catatonic to cultured keratinocyte skin cells.  It is not a dermal irritant, nor does it induce contact sensation.

The peptide is not a mammalian or bacterial mutagen.  Acute and chronic systemic toxicity studies have established a safe dose, which is a multiple of the efficacious dose for Flex S1,2.

In fact, Flex S1 falls under the FDA cosmetic designation according to the Federal Food, Drug, And Cosmetic Act (FD&C ACT).  The legal staff is evaluating Flex S2 at this time.

The safety trials for the more potent PEZ peptide have been arranged for January 2003.

All WSMR Related Stories:
 WSMR Press Release - Synthetic Peptide 
WSMR Frequently Asked Questions + Safety Profile
WSMR Flexible Peptide S patient results
WSMR received seal of approval from JTR
WSMR test patient request form
Dr. Kenneth Skinner of WSMR speaks about HairSwitch
Interim update from WSMR HairSwitch peptide trialist.
HairSite spoke to WSMR's HairSwitch peptide trialists.
March 1, 2003: first official update from HairSwitch peptide trialists.
November 2003: before and after photos.
Dr. Jankovic's comments about WSMR.


Alert:
Please be advised that HairSite is NOT recommending WSMR products to any of our readers. Please exercised caution if you are considering purchasing WSMR products as we are unable to verify if the product is indeed effective for hair growth or otherwise. Also, while there is no incriminating evidence which suggests that WSMR is a scam, we believe that our readers should familiarize themselves with the latest report by Rock Mountain News about WSMR. Click here for JTR's post.


TOPICAL FORUM

Information about this article

Article #  228
Title WSMR'S Synthetic Peptide Flex S1, 2 - FAQ + Safety Profile
Date 10/15/02
Source WSMR, reprinted with permission from WSMR
Forum Topical Forum
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