|
|
| Date |
Sep 18, 2001 |
| Article |
# 168 |
| Title |
Long
Term Use of Systematic 5-Alpha Reductase Inhibitors and Risk of
Immune Disorders |
| Forums |
Please use Propecia forum
<see top of this page> |
| Source |
Mr. Stephen I. Foote |
| Category |
Consumer Alert & Oral
Medications |
The
following email from Mr. Stephen Foote addressed concerns about long term
use of systematic 5-alpha reductase (finasteride) and risk of immune
disorders. The email was reprinted with minor modifications in order to
fit the format of our library.
Sep, 2001
Dear Hairsite.
Thank
you for your email of the 17 Sept. I am the author of the paper currently
published in HairSite. My research is currently being reviewed for
possible publication in the journal Medical Hypotheses.
Because
of the reaction this proposal has received to date, I would welcome the
support of HairSite in my quest for an answer to the "Bottom
Line" question that this generates.
The
predicted effect of 5-alpha reductase inhibitors like Finasteride
(Merck&Co) upon tissue immunology would confirm this proposed primary
action of DHT. This would have automatic therapeutic consequences in a
number of gender related conditions, including more effective targeting of
male hair loss.
Unfortunately,
this would also demonstrate that the long term use of systematic 5-alpha
reductase inhibitors would significantly increase risk of immune
disorders. This is not currently recognized in the data.
Through
my correspondence with Merck&Co and the drug licensing authorities, it
is clear that it is now known if Finasteride has this predicted effect or
not. The problem is that there is no legal obligation that specific
effects of drugs be disclosed, and to date there has been a consistent
refusal to respond to this question .I am now sure that if Finasteride did
not have this effect, this would have been willingly stated by now.
I
therefore now feel that a general awareness of this important question,
would help to generate a response to this, and I would welcome your
support here.
Best
wishes. Stephen Foote
2nd
email to HairSite:
Sep 2001
Dear Hairsite:
Please
invite your discussion group for feedback on this topic.
I have now been involved in this matter for over six years, and I
think a summary of documented events would be informative.
Initially the manufacturer of Propecia (Merck&Co) accepted this
explanation for the effects of DHT upon hair growth. I have a letter from
them in which they thank me for bringing this discovery to their
attention.
However, once it was realized that this would question the
effectiveness and long term safety of propecia, Merck&Co have refused
to comment further. The English drug control agency (the M.C.A.) assured
me that they would investigate this safety question.
At this time (Nov97), the publicity suggested that Propecia would
be available in England within weeks on private prescription. However you
will note that almost four years on, Propecia is still not being made
available in England as expected. Why?
This action of DHT suggests a strategy for the effective treatment
of male hair loss. In order to demonstrate the validity of this, it is
necessary to confirm the predicted effects of finasteride/propecia as
described in my paper. As it stands however, the relevant data is being withheld
because of existing interests.
Best Wishes Stephen Foote
To read Mr. Stephen Foote's analysis in full, please click:
The
Hydraulic Influence in Androgen Related Hair Growth. Implications in
Autoimmune Disease.
Any
comments, please use Propecia forum below.
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Clinically
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