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From: To All from Megan
Date: 11 Apr 2001
Time: 13:28:37
Remote Name: 63.23.130.216
Thank you all for your comments. I was taking alittle over 100mg elemental iron for 2 1/2 weeks and my hair shedding decreased dramatically and I know it was b/c of the iron. I started iron supplements almost 3 months ago. After about 2months I decreased my Iron supplement to alittle over 50 elemental iron. Now it has been almost 3 months and my hair is shedding a lot. As I mentioned before I just had my ferritin tested and it came back at 138. My TIBC was also very low- 297. 3 months ago my TIBC was really high 550 and my ferritin was low – 35. I did stop taking supplements for about 3 - 4 days before my tests. But I did have red meat during that time. I am so confused and extremely depressed- I don’t know how my husband puts up with me. Any advice would be greatly appreciated. Thanks again, Megan
From:
Date: 07 Aug 2001
Time: 05:22:45
Remote Name: 64.12.101.179
Anaemia due to iron, vitamin B12 or folate deficiency
What is anaemia? Red blood cells contain haemoglobin, which is the molecule that carries oxygen in the blood. The red cells travel through the lungs where the haemoglobin becomes oxygenated (picks up oxygen) and bright red in colour. The red cells are then pumped by the heart to the rest of the body where the haemoglobin gives up its oxygen to the tissues and becomes dark blue in the process.
‘Anaemia’ means that the level of red cells, and therefore of haemoglobin, in the blood is abnormally low. As a result the oxygen-carrying capacity of blood is reduced. Anaemia may be caused by excessive bleeding, by destruction of red cells or by decreased production of red cells. Anaemia caused by decreased production of red blood cells is discussed here. Anaemia from excessive bleeding is discussed in a separate Factsheet.
What causes anaemia and who is at risk? Decreased production of red cells is mainly caused by:
not enough iron (iron deficiency), vitamin B12 deficiency, or folic acid (a vitamin, also called folate) deficiency. For red blood cells to be produced by the bone marrow, many nutrients are needed, such as iron, vitamin B12 and folic acid. These are taken in by the body from food, and iron is also recycled from red cells that have died. Except for infants, a diet deficient in iron (which is predominantly found in red meat) does not cause anaemia. Generally, the only cause of iron-deficiency anaemia is chronic (prolonged) bleeding, during which the body’s supply of recycled iron is too low and the shortfall cannot be made up by the diet. Menstrual bleeding is the most common cause of iron-deficiency anaemia in women before the menopause, but after this and in men it is usually caused by bleeding from somewhere in the gut, such as a polyp (a benign growth), cancer of the large bowel or a peptic ulcer.
Chronic (prolonged) diseases, such as infections, rheumatoid arthritis and cancer, can cause iron-deficiency anaemia because the developing red cells in the bone marrow are unable to use the iron stores.
Red blood cells also need vitamin B12 and folic acid to mature. If either is lacking then an anaemia called ‘megaloblastic anaemia’ develops in which the red cells are large and abnormal (called ‘megaloblast cells’). The main cause of vitamin B12 deficiency anaemia is ‘pernicious anaemia’, in which there is inadequate absorption of vitamin B12 from the diet (mainly from meat and some vegetables).
Vitamin B12 binds a protein called intrinsic factor which is produced in the stomach; this complex of vitamin B12 and intrinsic factor travels to the small bowel where it is absorbed into the blood stream. Without intrinsic factor, vitamin B12 cannot be absorbed; in pernicious anaemia, the stomach does not produce intrinsic factor and so vitamin B12 is not absorbed, however much is taken in the diet.
This anaemia can often take more than two years to develop because there are large stores of vitamin B12 in the liver. In some diseases of the small bowel, such as Crohn’s disease, vitamin B12 absorption can be impaired. A strict vegetarian diet can also cause vitamin B12 deficiency.
A lack of folic acid, which is more common in the Western world than lack of vitamin B12, also leads to megaloblastic anaemia. The main cause is a diet poor in folic acid, which is mainly found in fresh fruit and raw vegetables. Reduced uptake of folic acid can be caused by excessive alcohol consumption and by certain medicines.
Some drugs used to treat cancer also cause megaloblastic anaemia.
What are the common symptoms and complications of anaemia? The symptoms of anaemia include:
tiredness, breathlessness, dizziness (especially when standing), and a weak, rapid pulse. Iron deficiency also causes:
inflammation of the tongue, cracks at the sides of the mouth, deformities of the fingernails, and pica (a craving for earth, ice or other non-foods). Vitamin B12 deficiency also causes:
damage to nerves (abnormal sensation and movement), sore tongue, pigmented skin, colour blindness, and depression, confusion and decreased intellectual function.
From: US
Date: 19 Jul 2006
Time: 03:21:02
Remote Name: 194.67.32.47
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